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PubMed · 12887916

Two poles and a compass.

Ruedi Meili·Richard A Firtel
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Abstract

Rho GTPases control fundamental aspects of neutrophil chemotaxis: establishment of front and back and orientation toward the chemoattractant. Two reports in this issue show that activated Cdc42 at the leading edge helps orient the cell's axis in a signaling complex with G beta gamma, PAK1, and PIX alpha; while Rho, activated via G alpha 13, mediates formation of the uropod, which then interacts by mutual negative feedback with the front to reinforce polarization (Li et al., 2003 [this issue of Cell]; Xu et al., [this issue of Cell]).

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Cell Cycle ProteinsCell PolarityChemotaxis, LeukocyteCytoskeletonDNA-Binding ProteinsGTP-Binding Protein alpha Subunits, G12-G13Guanine Nucleotide Exchange FactorsHumansNeutrophilsPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsSignal Transductioncdc42 GTP-Binding Proteinp21-Activated Kinasesrho GTP-Binding ProteinsrhoA GTP-Binding ProteinJournal ArticleComment

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Ruedi Meili, Richard A Firtel. 2003-07-25. Two poles and a compass.. https://doi.org/10.1016/s0092-8674(03)00553-1

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