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Cycling without CDK2?

Jonathan E Grim·Bruce E Clurman
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Abstract

Cyclin-dependent kinase 2 (CDK2) regulates diverse aspects of the mammalian cell cycle. Most cancer cells contain mutations in the pathways that control CDK2, and CDK2 activity has received much attention as a target for cancer therapy. However, a recent report demonstrating that some cancer cells can proliferate without CDK2 activity questions the essential role of CDK2 in cell-cycle control, as well as its suitability as a therapeutic target.

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AnimalsCDC2-CDC28 KinasesCell CycleCell Cycle ProteinsCell Line, TumorCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesCyclinsDNA-Binding ProteinsE2F Transcription FactorsG1 PhaseHumansModels, BiologicalNuclear ProteinsNucleophosminPhosphorylationProto-Oncogene ProteinsRetinoblastoma ProteinSaccharomyces cerevisiae ProteinsTranscription Factor DP1Transcription FactorsTumor Suppressor ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Comment

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Jonathan E Grim, Bruce E Clurman. 2003. Cycling without CDK2?. https://doi.org/10.1016/s0962-8924(03)00148-x

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