Lithiation study on D4T.

H Kumamoto; H Tanaka

doi:10.1093/nass/44.1.107

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PubMed · 12903291

Lithiation study on D4T.

H Kumamoto·H Tanaka

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Abstract

Upon treatment with LTMP, 5'-O-protected D4T undergoes deprotonation of the vinylic proton (H-3' or H-2'): when 5'-O-silyl derivative was used, the 3'-C-silylated product was formed as a result of C3'-lithiation and subsequent O-->C silyl migration, while deprotonation at the 2'-position led to the formation of an allene derivative. A stannyl version of this reaction was also examined to develop a method for C3'-functionalization of D4T.

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H Kumamoto, H Tanaka. 2000. Lithiation study on D4T.. https://doi.org/10.1093/nass%2F44.1.107

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