PubMed · 1291095
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
A Mitani. 1992. Glibenclamide and cardiac function during ischaemia.. https://doi.org/10.1093/cvr%2F26.11.1154
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
In this study, the synthesis of 15 new glibenclamide analogues is described. The conformational trends of these analogues were investigated using Monte Carlo conformational analysis. The conformational analysis results resolved the discrepancy between previous molecular modelling simulations of glibenclamide and allowed rationalizing the effect of aqueous environment on the overall conformation. The 3D-QSAR study was carried out with respect to the compounds' ability to antagonize the [(3)H]-glibenclamide binging in rat cerebral cortex. Superimposition of the antagonists was performed using the conformations derived from atom-by-atom fit to the glibenclamide crystal structure and this alignment was used to develop CoMFA models. CoMFA provided a good predictability: number of PLS components = 2, q(2) = 0.876, R(2) = 0.921, SEE = 0.455 and F = 70. Best CoMFA models showed the steric and lipophilic properties as the major interacting forces whilst the electrostatic property contribution was a minor factor.
A 45-year-old male, admitted for severe thrombocytopenia and bleeding tendency related to treatment with glibenclamide is presented. Thrombocytopenic purpura associated with glibenclamide, a short-acting sulfonylurea, is rare. We suggest that platelet counts be performed shortly after initiation of glibenclamide administration, and every 3 months thereafter.