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The renal cell primary cilium functions as a flow sensor.

Helle A Praetorius·Kenneth R Spring
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Abstract

PURPOSE OF REVIEW: To discuss recent reports on the function and importance of the renal primary cilium, a widely distributed organelle. RECENT FINDINGS: Most epithelial cells, including those in the kidney, express a solitary primary cilium. The primary cilium functions as a flow sensor in cultured renal epithelial cells (MDCK and mouse collecting tubule) mediating a large increase in intracellular calcium concentration. Flow sensing is shown to reside in the cilium itself and to involve the proteins polycystin 1 and 2, defects in which are associated with the majority of cases of human polycystic kidney disease. The role of the cilium in flow-dependent potassium secretion by the collecting tubule and in sensing of chemical components of the luminal fluid are also described. SUMMARY: The primary cilium is mechanically sensitive and serves as a flow sensor in cultured renal epithelia. Bending the cilium by mechanical means or flow causes a large, prolonged transient increase in intracellular calcium. The mechanically sensitive protein in the cilium is a polycystin.

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AnimalsCalcium ChannelsCalcium-Binding ProteinsCells, CulturedCiliaEpithelial CellsHumansKidneyMembrane ProteinsProteinsTRPP Cation ChannelsJournal ArticleReview

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Helle A Praetorius, Kenneth R Spring. 2003. The renal cell primary cilium functions as a flow sensor.. https://doi.org/10.1097/00041552-200309000-00006

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