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Thyroid hormone action: a binding contract.

Mitchell A Lazar
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Abstract

Thyroid hormones are critical for differentiation, growth, and metabolism. A new study investigating the biological role of the TH receptor TR-beta has demonstrated that DNA binding is critical for most of its functions, but also suggests that novel mechanisms independent of DNA binding may contribute to regulation of auditory function by TR-beta.

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AnimalsDNAHumansLigandsMiceMice, Mutant StrainsModels, BiologicalProtein BindingThyroid Hormone Receptors betaThyroid HormonesCommentJournal ArticleReview

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Mitchell A Lazar. 2003. Thyroid hormone action: a binding contract.. https://doi.org/10.1172/jci19479

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