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The host response to anthrax lethal toxin: unexpected observations.

Alice S Prince
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Abstract

Bacillus anthracis, the causative agent of anthrax, is believed to induce disease and death in humans in an endotoxic shock-like manner. A comprehensive study of the effects of anthrax toxin in mice demonstrates that toxin-induced death is mediated not by cytokine release, as previously thought, but by hypoxia-induced liver failure. The study strongly suggests that the therapies developed for treatment of cytokine-mediated septic shock will not be appropriate for the treatment of anthrax.

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AnimalsAnthraxAntigens, BacterialBacterial ToxinsMicePlasmidsTumor Necrosis Factor-alphaVirulence FactorsCommentJournal Article

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Alice S Prince. 2003. The host response to anthrax lethal toxin: unexpected observations.. https://doi.org/10.1172/jci19581

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