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PubMed · 12974799

HLA class I expression in bladder carcinomas.

T Cabrera·G Pedrajas·J M Cozar·A Garrido·J Vicente·M Tallada·F Garrido
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Abstract

HLA class I molecules are frequently lost in a large variety of human carcinomas, possibly because of T-cell immune selection of major histocompatibility complex class I deficient tumor variants. We report that this phenomenon is also a frequent event in bladder carcinomas. Of a total of 72 bladder carcinomas, 72% of the tumors had at least one alteration in HLA class I expression. These altered HLA class I phenotypes were classified as total HLA class I loss (25%; phenotype I); HLA-A or/and HLA-B locus-specific loss (12%; phenotype III); and HLA class I allelic loss (35%; phenotype II or IV). Comparison of histopathological parameters with HLA class I expression showed a statistically significant relationship with the degree of differentiation and tumor recurrence.

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CarcinomaGenes, MHC Class IHLA AntigensHistocompatibility Antigens Class IHumansUrinary Bladder NeoplasmsJournal ArticleResearch Support, Non-U.S. Gov't

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T Cabrera, G Pedrajas, J M Cozar, A Garrido, J Vicente, M Tallada, F Garrido. 2003. HLA class I expression in bladder carcinomas.. https://doi.org/10.1034/j.1399-0039.2003.00104.x

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