PubMed · 13348248
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
T BENZI. 1956-05-19. [Appendicitis in aged].. https://pubmed.ncbi.nlm.nih.gov/13348248/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Specific immunotherapies for patients with acute myeloid leukemia (AML) using leukemia-associated antigens (LAA) as target structures might be a therapeutic option to enhance the graft-vs.-leukemia effect observed after allogeneic stem cell transplantation or to prolong a complete remission (CR) achieved by chemotherapy. Significant mRNA expression of LAA is a prerequisite for such immunotherapies. Here, previously characterized antigens associated with solid tumors (TAA) and newly characterized LAA were investigated for their expression in up to 60 AML patients and in leukemia cell lines. To investigate their specificity for leukemic blasts, the mRNA expression was also characterized in PBMN and CD34 positive cells of healthy volunteers and in a panel of normal tissues. The following antigens showed high mRNA expression in AML patients: MPP11 was detected in 43/50 (86%), RHAMM in 35/50 (70%), WT1 in 40/60 (67%), PRAME in 32/50 (64%), G250 in 18/35 (51%), hTERT in 7/25 (28%) and BAGE in 8/30 (27%) of AML patients. Real-time RT-PCR showed a tumor-specific expression of the antigens BAGE, G250 and hTERT, as well as highly tumor-restricted expression for RHAMM, PRAME and WT1. The antigen MPP11 was overexpressed. These antigens might be candidates for immunotherapies of leukemia patients and, because of their simultaneous expression, also for polyvalent vaccines.
The effect of diesel exhaust particulate (DEP) exposure on innate, cellular and humoral pulmonary immunity was studied using high-dose, acute-exposure rat, mouse, and cell culture models. DEP consists of a complex mixture of petrochemical-derived organics adsorbed onto elemental carbon particles. DEP is a major component of particulate urban air pollution and a health concern in both urban and occupational environments. The alveolar macrophage is considered a key cellular component in pulmonary innate immunity. DEP and DEP organic extracts have been found to suppress alveolar macrophage function as demonstrated by reduced production of cytokines (interleukin-1 [IL-1], tumor necrosis factor- alpha [TNF- alpha]) and reactive oxygen species (ROS) in response to a variety of agents, including lipopolysaccharide (LPS), interferon- gamma (IFN- gamma), and bacteria. Fractionation of DEP organic extract suggests that this activity was predominately in polyaromatic-containing and more polar (resin) fractions. Organic-stripped DEP did not alter these innate pulmonary immune responses. DEP also depressed pulmonary clearance of Listeria monocytogenes and Bacillus Calmette-Guerin (BCG). The contribution of the organic component of DEP is less well defined with respect to acquired and humoral immunity. Indeed, both DEP and carbon black enhanced humoral immune responses (specific immunoglobulin [Ig] E and IgG) in an ovalbumin-sensitized rat model. It is concluded that both the particulate and adsorbed organics may contribute to DEP-mediated immune alterations.
The adrenocortical response to acute stress as measured by increase in plasma levels of corticosterone following capture, handling, and restraint over an hour was estimated in free-living male bush warblers at different times of the breeding season on their breeding ground in Chichibu, Honshu, Japan. Initial plasma levels of corticosterone showed a seasonal change, being moderate in April, highest in May to July and declined in late August. In contrast, the stress response was suppressed at the early stage of the breeding season, April and May, and just after the breeding season, late August. In June, July, and early August, the response was obvious although the initial levels of corticosterone were high. These results are different from those of monogamous passerine birds so far studied in which adrenocortical response is obvious at the early stage of breeding season and the response is suppressed later stage when the male is involved in parental care. The results suggest that during a course of the breeding season, male bush warblers that take a polygynous breeding strategy may decrease the amplitude of the adrenocortical response to acute stress at the early stage of the breeding season so as to allow establishment and defense of a territory. The birds became more sensitive to acute stress later the breeding season when they already had females incubating, feeding hatchlings or even fledgling. This change of stress response is likely to be a reflection of polygynous breeding strategy of the species.