PubMed · 13348439
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N ORLANDI. 1956-06-30. [Malignant embryonic nephroblastoma (rabdomyoblastic adenosarcoma)].. https://pubmed.ncbi.nlm.nih.gov/13348439/
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Adenosarcoma is a rare uterine biphasic tumor composed of benign epithelial elements and a sarcomatous stroma. Although it is well described histologically, its cytological features are rarely mentioned in the literature. We describe a case of uterine adenosarcoma that was first detected by Papanicolau (Pap) smear. Numerous crowded clusters of spindle cells were present within a bloody background, as well as a few smaller, dyscohesive groups with cells showing high N:C ratio and oval to round nuclei with coarse chromatin and small nucleoli. A few nuclear grooves were identified. Adenosarcomas are rare lesions but should be considered in the differential diagnosis when spindled cells are noted in a pap smear.
BACKGROUND: Adenosarcoma arising in inguinal endometriosis is a rare clinical entity. CASE: A 47-year-old nulligravida presented with a persistent and enlarged right groin mass. Sixteen years earlier she had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy for endometriosis and was placed on estrogen therapy. Surgical en bloc excision of the 12 x 4 cm inguinal mass revealed adenosarcoma arising in endometriosis. CONCLUSION: Although a rare entity, adenosarcoma arising in inguinal endometriosis should be included in the differential diagnosis for those patients with a history of endometriosis and chronic unopposed estrogen therapy who present with a groin mass.
BACKGROUND: Uterine Mullerian adenosarcoma (UMA) is a rare and low-grade variant of mixed mesodermal tumor. UMA recurrences including heterologous sarcomatous elements are extremely rare, with only 3 cases reported thus far. CASE: We present a case of UMA recurring as heterologous sarcoma three times in 8 months for 9.4 years after primary treatment. The number and grade of sarcomatous components increased with each recurrence eventually resulting in loss of the patient. CONCLUSION: The presence of multiple sarcomatous elements of high histological grade in the recurrent tumor following UMA may indicate an unfavorable prognosis with common recurrences and fatal outcome. All UMA patients carry risk of late recurrence, therefore, they should receive long-term follow-up.