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PubMed · 13390255

[Simple degenerative diffuse sclerosis; its differentiation from leukodystrophy].

G W EDGAR·C POSER·J RADERMECKER·L VAN BOGAERT·J VAN MIERT
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Brain DiseasesCentral Nervous System DiseasesDemyelinating DiseasesDiagnosis, DifferentialDiffuse Cerebral Sclerosis of SchilderHumansLysosomal Storage DiseasesSclerosisCENTRAL NERVOUS SYSTEM/diseasesENCEPHALITIS PERIAXIALIS/differential diagnosisJournal Article

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G W EDGAR, C POSER, J RADERMECKER, L VAN BOGAERT, J VAN MIERT. 1956. [Simple degenerative diffuse sclerosis; its differentiation from leukodystrophy].. https://pubmed.ncbi.nlm.nih.gov/13390255/

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PubMed2003

Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy.

BACKGROUND: Risk factors for temporal lobe epilepsy (TLE) include history of CNS infection, family history of epilepsy, and history of febrile convulsions (FC). Pre-existing cortical dysplasia (CD) may also predispose to refractory TLE, independent of other risk factors for epilepsy. METHODS: The authors reviewed the neuropathologic features of surgical tissue from temporal lobectomies of 33 pediatric patients with refractory TLE, with and without a history of epilepsy risk factors. RESULTS: CD was found in 64% (21/33) of all patients with refractory TLE, including 73% (11/15) patients with a history of FC, 66% (2/3) patients with CNS infections, and 83% (5/6) patients with a family history of epilepsy. Disrupted cortical lamination, dystrophic and maloriented neurons, and balloon cells characterized the CD found in the temporal neocortex. CONCLUSION: CD was seen in 21 of 33 surgical specimens from children with refractory TLE, including those with and without other epilepsy risk factors.

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