PubMed HealthSearch

PubMed · 1341124

[Witch hunt].

Abstract

Owing to its sinister characteristics, as well as its temporal pertaining to the Modern Age, the Witch-Hunt historical episode has become an embarrassing affair for our supposedly rational beings' self-esteem. Long lastingly, therefore, Witch-Hunt has been either overpassed straight away or just attributed to violent and pathological a manifestation of collective craze as its own name indicates. Lately, though, many authors have met the challenge of finding out a rational background thereof, actually unearthing coldly calculated, relentlessly pursued outweighing political and economic interests. It is the author's contention that a serene, diligent consideration of all hypotheses that have been set before the connection with this episode--together with their very inherent disparities--could (apart from their own heuristic values) contribute eventually to both sharpening and broadening the understanding of our human condition, complex and fragile as it is.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

B Edelstein. 1992. [Witch hunt].. https://pubmed.ncbi.nlm.nih.gov/1341124/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Molecular diagnosis of spinal muscular atrophy: Experience in a pediatric hospital in Argentina.

Introduction. Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease caused by the loss of the SMN1 gene, with a variable clinical spectrum determined primarily by the number of copies of the SMN2 gene. The development of new therapies underscores the importance of early molecular diagnosis and genotype-phenotype characterization. Objective. To describe 27 years of experience in the molecular diagnosis of SMA at a pediatric referral hospital in Argentina and to evaluate the correlation between SMN2 copy number and the SMA types.Population and methods. A retrospective descriptive study was conducted on 1060 pediatric patients with clinically suspected SMA who were evaluated between 1997 and 2024. Molecular diagnosis was performed using PCR-RFLP and, since 2012, MLPA to determine SMN1 and SMN2 copy number. Genotype-phenotype correlation was evaluated in 260 patients with complete clinical characterization. Results. The diagnosis was confirmed in 513 patients. A homozygous deletion of the SMN1 gene was detected in 99.6% of unrelated cases. The positivity rate increased over time. A significant correlation was observed between the number of SMN2 copies and the type of SMA, with milder phenotypes associated with a higher number of copies. Conclusion. Molecular diagnosis of SMA enabled accurate and timely characterization of patients, avoiding invasive procedures and optimizing therapeutic decision-making. Genotype-phenotype correlation is a fundamental tool for prognosis and clinical management, highlighting the importance of an interdisciplinary approach.

Argentina