PubMed · 13458336
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J A LEE, P CAVER, W L NOBLES. 1957. A simplified, powdered, washable ointment base.. https://pubmed.ncbi.nlm.nih.gov/13458336/
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The aim of the study was to evaluate the usefulness of hydrophilic base with pilocarpine hydrochloride. Comparisons were made between releasing rate of pilocarpine hydrochloride from hydrophilic and lipophilic bases into water and artificial tears. It was found that pilocarpine hydrochloride was released in the amount 30-40 times greater from hydrogel bases compared to lipophilic. The releasing rate of drugs from hydrogel ointments increases with the increased colloid concentration and with decreased of drug concentration in the base.
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