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PubMed · 1384236

Second-generation anti-HCV tests predict infectivity.

J Larsen·K Skaug·A Maeland
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Abstract

Twenty-four blood donors found positive for the first-generation hepatitis C antibody (anti-HCV) test (Ortho EIA-I) and 88 of their recipients over the period from 1972 to 1990 were retrospectively investigated with different first- and second-generation anti-HCV tests. The aim of the study was to identify the infective donors and to evaluate the tests. Seven donors, who probably were infective carriers of HCV, were also second-generation test (EIA-II) positive, compared to only 3 out of 17 noninfective donors. Among the infected recipients, 14 out of 29 (48%) were positive for the second-generation test only. The second-generation test identified the infective donors in our study and was more sensitive than the first-generation test. We therefore recommend that blood donors are screened with EIA-II. Positive test results should be confirmed by the recombinant immunoblot assay (RIBA-II), and persons with positive or not conclusive RIBA-II should not be accepted as blood donors.

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BloodBlood DonorsHepacivirusHepatitis AntibodiesHepatitis C AntibodiesHumansImmunoblottingImmunoenzyme TechniquesJournal Article

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BibTeXRIS

J Larsen, K Skaug, A Maeland. 1992. Second-generation anti-HCV tests predict infectivity.. https://doi.org/10.1111/j.1423-0410.1992.tb01216.x

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