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PubMed · 1388652

Autoimmunity and the ovary.

R Moncayo·H E Moncayo
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Abstract

The ovary was first documented as a target of autoimmunity over three decades ago yet today the aetiology and pathogenesis of autoimmune-mediated premature ovarian failure (POF) are poorly understood. Here, Roy and Helga Moncayo provide a brief overview of human autoimmune-mediated POF and the animal models of POF. They propose a model for the development of the disease, highlighting the role of supraphysiological levels of gonadotropins in inducing selectively antigenic mature ovarian elements.

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AnimalsAutoantibodiesAutoimmune DiseasesCyclosporineDisease Models, AnimalDrug ResistanceFemaleGonadotropins, PituitaryHumansImmunizationMenopause, PrematureMiceMice, NudeOvaryOvulation InductionT-Lymphocyte SubsetsThymectomyThymus GlandJournal ArticleReview

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R Moncayo, H E Moncayo. 1992. Autoimmunity and the ovary.. https://doi.org/10.1016/0167-5699(92)90006-s

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