PubMed · 14080362
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H E HART, C A WELLER. 1963. RECENT DEVELOPMENTS IN MULTI-COMPARTMENT TRACER ANALYSIS.. https://doi.org/10.1111/j.2164-0947.1963.tb01234.x
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Purpose of this paper is to characterize the Ion-Sensitive Field-Effect Transistors (ISFET)-neuron junction, based on the equivalent electric-circuit approach. As a result, recording of action potentials can be simulated with a general-purpose circuit simulation program such as HSPICE. The neuronal electrical activity, extracellularly recorded by the ISFET, is analyzed as a function of the physical-chemical and geometric ISFET parameters, of the ionic currents in the neuron, and of the neuro-electronic junction parameters such as the sealing resistance, double-layer capacitance, and general adhesion conditions. The models of the neuron, of the coupling circuit, and of the ISFET implemented in HSPICE are first described. These models are then used to simulate the behavior of the junction between a patch of neuronal membrane (described by the compartmental model) and the ISFET.
A detailed study of the potential energy surfaces involved in the di-pi-methane rearrangement (singlet and triplet states) reveals the factors that modulate the mechanisms (pathways) and reactivity in strained di-pi-methane systems such as bicyclo[2.2.2]octa-2,5,7-triene (barrelene). [structure: see text]
Multivariate resolution methods make up a set of mathematical tools that may be applied to the analysis and interpretation of spectroscopic data recorded when monitoring a physical or chemical process with multichannel detectors. The goal of resolution methods is the recovery of chemical and/or physical information from the experimental data. Such data include, for example, the number of intermediates present in a reaction, the rate or equilibrium constants, and the spectra for each one of those intermediates. Multivariate resolution methods have been shown to be useful for the study of biophysical and biochemical processes such as folding/unfolding of proteins or nucleic acids. The present article reviews the most frequently used resolution methods, the limitations on their use, and their latest applications in protein and nucleic acid research.