PubMed · 14245216
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R DOLL, M C PIKE. 1965-03-13. SOMATIC MUTATION.. https://doi.org/10.1136/bmj.1.5436.723-b
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AIM: To assess whether intraocular pressure (IOP) is associated with refractive error or axial length in children. METHODS: Of subjects from the Singapore Cohort Study of the Risk Factors for Myopia (SCORM), 636 Chinese children aged 9-11 years from two elementary schools underwent non-contact tonometry, cycloplegic autorefraction, and A-scan biometry during 2001. For analyses, refractive error was categorised into four groups; hypermetropia (spherical equivalent refraction (SE) > or = +1.0D), emmetropia (-0.5D<SE< +1.0D), low myopia (-3.0D<SE< or = -0.5D) and high myopia (SE< or = -3.0D). RESULTS: Of the 636 children examined, 50.6% were male. The mean IOP was 16.6 (SD 2.7) mm Hg. There were no significant IOP differences between low (mean IOP = 16.4 (2.8) mm Hg) or high myopes (16.7 (2.5) mm Hg) and emmetropes (16.7 (2.9) mm Hg), p = 0.57. IOP was not correlated with spherical equivalent refraction (Spearman correlation, r = 0.009) or axial length (r = 0.030). In regression analyses adjusting for diastolic blood pressure, neither spherical equivalent (regression coefficient = 0.014) nor axial length (regression coefficient = 0.027) were significantly associated with IOP. CONCLUSION: These findings do not support an association between IOP and refractive error or axial length in children. This questions postulated roles of IOP in the pathogenesis of myopia.
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Sam Greenhouse joined the Census Bureau as a clerk at an interesting time period for the agency. The first use of sampling in the decennial census occurred in 1940. There was a major expansion of the amount of data collected. The organization of the Census Bureau underwent radical changes, including the growth of the Population Division of which Greenhouse was a part, and the Office of Statistical Assistant was established. After the 1940 census Greenhouse was also part of a new intercensal program which became the forerunner of today's Current Population Survey, and was on hand for the transition of the physical location of the agency from Washington D.C. to Suitland, Maryland. After America's entry into World War II, Sam Greenhouse left the Census Bureau and worked with the United Nations Relief and Rehabilitation Administration (UNRRA), designed to manage the support and eventual repatriation of refugees who would come under Allied control at the war's end. Published in 2003 by John Wiley & Sons, Ltd.