PubMed · 14338620
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A JAKOB, M BENEVENIA, E SAVRANSKY. 1965. [ELECTROCOAGULATION WITHOUT PREVIOUS DIAGNOSIS].. https://pubmed.ncbi.nlm.nih.gov/14338620/
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The interest of the postcoital test (PCT) has been subject to debate in the last ten years. In France, it is considered as part of the basic fertility work-up, since it is no longer recommended as routine investigation in English literature. However, there is no evidence-based demonstration to support the test being ostracized. PCT is still useful as a diagnostic tool to control intercourse, quantify sperm concentration and evaluate sperm mobility in the cervical mucus.
OBJECTIVE: Several intratype variants of HPV16 and 18 have been identified. These variants are associated with populations from different geographic regions, and show a differential distribution among the severity of the cervical lesion, most likely due to different pathogenic potential. The objective of this study was to investigate the variant distribution of HPV16 and 18 in a Mexican population and its association with the severity of the cervical lesion and the histological lineage of cervical cancer. METHODS: HPV types 16 and 18 detection was performed in 412 samples of preinvasive and invasive specimens from patients attending a Primary Health-Care Center, an Early Cervical Lesion Clinic, or a Cancer Center. Distribution of HPV variants was correlated with the cytological findings and tumor cell types using contingency tables. Statistical difference was tested with the Fisher's Exact Test or its Fisher-Freeman-Halton extension for RXC tables. Alpha value was set at the P < 0.05. RESULTS: Among the 277 women included in this study without cancer, 63.5% (176 cases) had a normal cytology; from the remaining 101 women, 53.5% were LSIL (54 cases), and 46.5% HSIL (47 cases). From a total of 135 invasive carcinomas, 78.5% were squamous (106 cases); 6.6% adenocarcinoma (9 cases); 9.6% adenosquamous (ADSC) (13 cases); and 5.1% were undifferentiated carcinoma (7 cases). HPV16 E and AA-a were evenly distributed among preinvasive and invasive lesions. However, the isolate AA-c was exclusively found in cervical cancer. HPV18 Var-1(E) was almost exclusively found in invasive lesions, while the HPV18 Var-2(Af) predominated in normal or preinvasive lesions. In invasive cancer, this variant was found only in squamous tumors. CONCLUSIONS: The differential distribution of HPV16 and 18 variants in cervical lesions we found further supports experimental data on the different pathogenic potential of HPV16 and 18 variants for cervical cancer development.
PURPOSE: Excess laxity in the volar oblique ligament may predispose the thumb to trapeziometacarpal joint osteoarthritis. A greater prevalence of trapeziometacarpal joint osteoarthritis in women suggests a hormonal cause and relaxin is a hormone that may have some involvement. This conclusion emerges from relaxin's diverse tissue tropism, stimulation of collagenase production in cultured fibroblasts, and reports of increased joint laxity during pregnancy. We used immunohistochemistry to assess the potential of the volar oblique ligament to bind relaxin. METHODS: Eight volar oblique ligaments were obtained intraoperatively from perimenopausal women having basal joint arthroplasty with ligament reconstruction using the flexor carpi radialis tendon. Tissue specimens were snap-frozen in liquid nitrogen and stored at -80 degrees C until processing. Specimens then were cryosectioned, treated with a chelating rinse, incubated overnight with recombinant human relaxin, fixed, blocked, and exposed to antirelaxin antibody. Treatment with a universal aminoethylcarbizole staining kit was used to visualize areas of ligament-ligand binding. Both tissue and procedural controls served to establish binding specificity. RESULTS: Abundant staining was observed with the positive control (cervix) and all 8 volar oblique ligaments. Little or no staining was present in fibrocartilage (negative control) or procedural controls. CONCLUSIONS: Relaxin binds to the volar oblique ligament with specificity, implying a receptor-mediated process. Limitations of the procedure could not confirm binding saturability, necessitating additional study.