Pediatric pulmonary function testing in asthma.

G A Mueller; H Eigen

doi:10.1016/s0031-3955(16)38443-7

Home/Archive/PubMed

PubMed · 1437318

Pediatric pulmonary function testing in asthma.

G A Mueller·H Eigen

View original source ↗Export metadata ↓

Abstract

Pulmonary function testing is an important tool in the management of asthma. Lung function can be readily assessed in both the office and patient's home. This article reviews spirometry, peak flow meters, and bronchial challenge testing. Their interpretation and clinical use are presented as well.

Explore related subjects

Albuterol Asthma Bronchial Hyperreactivity Bronchial Provocation Tests Child Humans Infant Respiratory Function Tests Spirometry Journal Article Research Support, Non-U.S. Gov't Review

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

G A Mueller, H Eigen. 1992. Pediatric pulmonary function testing in asthma.. https://doi.org/10.1016/s0031-3955(16)38443-7

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Muscling in on salbutamol.

Explore the source record for details and available documents.

Albuterol↗

PubMed1992

Muscling in on salbutamol.

Explore the source record for details and available documents.

Albuterol↗

PubMed1992

Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea.

The effects of cromakalim, verapamil and salbutamol have been examined in guinea pig trachealis smooth muscle in both Krebs physiological salt solution and Krebs solution where K+ has been replaced by Rb+. Cromakalim-induced relaxation in the presence of Rb+ was reduced in extent and became transient, whilst the relaxation response to verapamil was enhanced and that to salbutamol unaffected. The transient relaxation occurring in Rb+ was blocked by quinidine and glibenclamide. The presence of extracellular Rb+ also prevented cromakalim-stimulated efflux of both 86Rb+ and 42/43K+. There was, however, no effect on cromakalim-stimulated 86Rb+ uptake. It is proposed that cromakalim is opening two populations of potassium channel in guinea pig tracheal smooth muscle, one of which is susceptible to blockade by Rb+ and one of which is not. The latter channel appears to play the dominant role in cromakalim-stimulated uptake, and is responsible for the transient relaxation response in the presence of rubidium, whilst the former is responsible for the maintained relaxation.

Albuterol↗