PubMed · 14431895
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H B PERLMAN. 1960. Physiological basis for tubal function tests.. https://doi.org/10.1001/archotol.1960.03770030026006
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A case of melanin pigmented oncocytic metaplasia is reported. A 62-year-old man presented with a history of discomfort of the ear of a 2 weeks' duration. Nasoscopic examination revealed a black nodule of about 5mm at the left Eustachian opening, and several black spots were discovered around the bilateral torus tubarius. The nodule was biopsied to determine the histology. Microscopically, there were oncocytic cells with abundant pigmented granules showing glandular pattern. Such a pigmented variant of benign oncocytic lesion is very rare.
There has been a recent surge in research on surfactant and surfactant proteins. Fields ranging from immunology to surface chemistry are making contributions to our understanding of this multifunctional compound. This paper reviews the literature on the structure and function of Eustachian tube surfactant. It covers the proposed functions of endogenous surfactant in normal physiology, as well as the experimental applications of exogenous surfactant in the treatment of otitis media. The analysis is based on four platforms of research: the role of surfactant in the innate immune system, the effect of surfactant on surface tension and Eustachian tube opening pressure, the capacity of surfactant to alter the rheological properties of mucus and the efficiency of the mucociliary system, and the ability of surfactant to mitigate oxygen free radical damage.
Central to many pathologic conditions affecting the middle ear is the failure of the ET to perform its functions of regulation of middle ear pressure, clearance of middle ear secretions, and protection of the middle ear space. Recent advances in radiologic imaging and fiberoptic endoscopes have allowed a more detailed description of the structure and function of this area. Hopefully, with the knowledge gained from advances in this area, more effective medical treatment options for common otologic problems, such as otitis media, will become available.