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PubMed · 14502829

Copper interaction on the long-term potentiation.

J Leiva·P Gaete·M Palestini
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Abstract

The role of copper on the CA1 piramidal neurons and their sinaptic connections to the Schaffer's collateral was investigated using the field excitatory post-sinaptic potential (fEPSP). The same fEPSP was used to study copper effects on Long-term potentiation (LTP). We have found that copper 10 microM has an inhibitory action on the fEPSP. Similar effects were demonstrated with 10 microM of GABA. Moreover, copper showed a strong inhibitory action on the consolidated LTP. However, copper washout left a significant and persistent excitatory response. In our opinion, copper shows a dual sinaptic effect depending on the sinaptic experience.

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AnimalsCopperCopper SulfateDose-Response Relationship, DrugDrug InteractionsExcitatory Postsynaptic PotentialsHepatolenticular DegenerationHippocampusLong-Term PotentiationNeural InhibitionNeurodegenerative DiseasesOrgan Culture TechniquesPresynaptic TerminalsPyramidal CellsRatsRats, WistarReaction TimeUp-Regulationgamma-Aminobutyric AcidJournal Article

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J Leiva, P Gaete, M Palestini. 2003. Copper interaction on the long-term potentiation.. https://pubmed.ncbi.nlm.nih.gov/14502829/

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