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PubMed · 14531461

Modified release bi-layered tablet of melatonin using beta-cyclodextrin.

A Kumar·S P Agarwal·R Khanna
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Abstract

A modified release bi-layered tablet of melatonin incorporating a fast release fraction consisting of melatonin-beta-cyclodextrin inclusion complex and a slow release fraction containing melatonin in HPMC K15M and Carbopol 971 P matrices was prepared. The formulation developed showed an initial burst followed by a near zero order release pattern for a period of 8 h. The drug content, physical characteristics and the release profile were unaffected after 3 months of an accelerated stability study at 40 degrees C and 75% relative humidity.

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Acrylic ResinsAntioxidantsCalorimetry, Differential ScanningChemistry, PharmaceuticalCyclodextrinsDelayed-Action PreparationsDrug StabilityExcipientsKineticsLactoseMelatoninMethylcelluloseMicroscopy, Electron, ScanningOxazinesPolyvinylsSolubilitySpectroscopy, Fourier Transform InfraredTabletsbeta-CyclodextrinsJournal ArticleResearch Support, Non-U.S. Gov't

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A Kumar, S P Agarwal, R Khanna. 2003. Modified release bi-layered tablet of melatonin using beta-cyclodextrin.. https://pubmed.ncbi.nlm.nih.gov/14531461/

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