Mesoangioblasts--vascular progenitors for extravascular mesodermal tissues.

Giulio Cossu; Paolo Bianco

doi:10.1016/j.gde.2003.08.001

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Mesoangioblasts--vascular progenitors for extravascular mesodermal tissues.

Giulio Cossu·Paolo Bianco

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Abstract

Mesoangioblasts are multipotent progenitors of mesodermal tissues that express the key marker of angiopoietic progenitors, Flk1 (VEGF-receptor 2), and are physically associated with the embryonic dorsal aorta in avian and mammalian species. When transplanted in vivo, they give rise to multiple differentiated mesodermal phenotypes. Their ability to extensively self-renew in vitro, while retaining multipotency, qualifies mesoangioblasts as a novel class of stem cells. Mesoangioblasts disclose not only an unexpected source of progenitors for skeletal muscle and a variety of other mesoderm-derived tissues, but also establish a lineage kinship between progenitors of vascular and extravascular mesodermal tissues, with important basic and applicative implications.

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Animals Aorta Blood Vessels Bone Marrow Cells Humans Mesoderm Stem Cells Journal Article Research Support, Non-U.S. Gov't Review

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Giulio Cossu, Paolo Bianco. 2003. Mesoangioblasts--vascular progenitors for extravascular mesodermal tissues.. https://doi.org/10.1016/j.gde.2003.08.001

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