Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.

Tsi-Shu Huang; Susan Shin-Jung Lee; Hui-Zin Tu; Wen-Kuei Huang; Yao-Shen Chen; Chung-Kai Huang; Shue-Ren Wann; Hsi-Hsun Lin; Yung-Ching Liu

doi:10.1128/aac.47.11.3672-3673.2003

PubMed · 14576145

Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.

Tsi-Shu Huang·Susan Shin-Jung Lee·Hui-Zin Tu·Wen-Kuei Huang·Yao-Shen Chen·Chung-Kai Huang·Shue-Ren Wann·Hsi-Hsun Lin·Yung-Ching Liu

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Abstract

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

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Amidohydrolases Antitubercular Agents DNA, Bacterial Drug Resistance, Bacterial Drug Resistance, Multiple, Bacterial Genotype Mutation Mycobacterium tuberculosis Pyrazinamide Reverse Transcriptase Polymerase Chain Reaction Taiwan Tuberculosis Journal Article Research Support, Non-U.S. Gov't

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Tsi-Shu Huang, Susan Shin-Jung Lee, Hui-Zin Tu, Wen-Kuei Huang, Yao-Shen Chen, Chung-Kai Huang, Shue-Ren Wann, Hsi-Hsun Lin, Yung-Ching Liu. 2003. Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.. https://doi.org/10.1128/aac.47.11.3672-3673.2003

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