PubMed · 14616174
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Richard Fuller. 2003. Conversation with Richard Fuller.. https://doi.org/10.1046/j.1360-0443.2003.00546.x
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AIMS: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. METHODS: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. RESULTS: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. CONCLUSIONS: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.
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