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Mixing efficiency in side-vented coating equipment.

George W Smith·Graeme S Macleod·John T Fell
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Abstract

The purpose of this study was to evaluate tablet mixing within side-vented coating equipment by assessing the development of color uniformity during coating. A colorimetric method was used to evaluate the time for uniform coating for different mixing baffle systems at different scales of equipment. The influence of tablet size was also determined. The inclusion of rabbit ear baffles in the small-scale equipment reduced the time to achieve color uniformity by 20 minutes. The design of baffle influenced the time for uniform color with a mixing efficiency rank order of tubular > ploughshare > rabbit ear. Upon scale-up, the efficiency of mixing seen at development scale remained equivalent in terms of the influence of baffle design. The study into the influence of tablet size revealed the importance that the total batch surface area has on the time taken to achieve color uniformity, with 7-mm diameter tablets having a higher surface area for an equivalent volume of product and taking 15 to 20 minutes longer to achieve color uniformity than 16-mm diameter tablets.

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ColorDrug CompoundingEquipment DesignReproducibility of ResultsSurface PropertiesTablets, Enteric-CoatedTechnology, PharmaceuticalTime FactorsEvaluation StudyJournal Article

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George W Smith, Graeme S Macleod, John T Fell. 2003. Mixing efficiency in side-vented coating equipment.. https://doi.org/10.1208/pt040337

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