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Vessel wall morphometry in giant cell arteritis.

C Nordborg·V Petursdottir
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Abstract

OBJECTIVE: To investigate morphometrically the relationship between the degree of inflammatory reaction and arterial cross-sectional dimensions in giant cell arteritis (GCA). METHODS: The media and intima of cross-sectioned inflamed arteries from GCA patients were outlined. The media circumference and the media and intima cross-sectional areas were measured. The two segments in every biopsy displaying the least and most widespread media inflammation were compared, using a paired Student's t-test. Moreover, paired comparisons were made of the intima area in inflamed and noninflamed sectors in single cross-sections. RESULTS: The segment in each biopsy showing the most widespread media inflammation had the largest circumference and volume of media and intima; the intima cross-sectional area increased disproportionately. The intima was thickest in inflamed sectors in single cross-sections. CONCLUSION: The close spatial correlation between inflammatory media infiltration and the marked intimal expansion supports the contention that promoting factors produced by inflammatory cells play a pathogenetic role in GCA.

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AgedAged, 80 and overBiopsyFemaleGiant Cell ArteritisHumansHyperplasiaInflammationInflammation MediatorsMaleMiddle AgedSeverity of Illness IndexTemporal ArteriesTunica IntimaTunica MediaCommentJournal ArticleResearch Support, Non-U.S. Gov't

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C Nordborg, V Petursdottir. 2000. Vessel wall morphometry in giant cell arteritis.. https://doi.org/10.1002/1529-0131(200010)13%3A5%3C286%3A%3Aaid-anr7%3E3.0.co%3B2-m

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