The DDAH/ADMA/NOS pathway.

Cam T L Tran; James M Leiper; Patrick Vallance

doi:10.1016/s1567-5688(03)00032-1

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The DDAH/ADMA/NOS pathway.

Cam T L Tran·James M Leiper·Patrick Vallance

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Abstract

An increasing number of reports in the literature indicate that endogenously produced inhibitors of nitric oxide synthase (NOS), particularly asymmetric dimethylarginine (ADMA) regulate nitric oxide generation in numerous disease states. Two dimethylarginine dimethylaminohydrolase (DDAH) enzymes metabolise ADMA. We and others have postulated that activity of DDAH is a key determinant of ADMA levels in vivo. This review summarises recent advances in the regulation and function of DDAH enzymes and its role in the regulation of nitric oxide generation.

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Amidohydrolases Animals Arginine Blood Pressure Endothelial Cells Endothelium, Vascular Enzyme Inhibitors Humans Nitric Oxide Synthase Vasodilation Journal Article Research Support, Non-U.S. Gov't Review

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Cam T L Tran, James M Leiper, Patrick Vallance. 2003. The DDAH/ADMA/NOS pathway.. https://doi.org/10.1016/s1567-5688(03)00032-1

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