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PubMed · 14670294

Molecular interactions: stiff or floppy (or somewhere in between?).

David H Margulies
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Abstract

Recognition of MHC and MHC-like molecules by both natural killer (NK) and T cell receptors (TCR) reveals remarkable degeneracy. The interaction of the NKG2D NK receptor with several MHC I-like ligands has now been analyzed thermodynamically by McFarland and Strong, who suggest that a "rigid adaptation" mechanism governs such crossreactivity. This contrasts with "induced fit" that accounts for TCR adaptation to multiple MHCp ligands.

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Histocompatibility AntigensKiller Cells, NaturalProtein BindingReceptors, Antigen, T-CellT-LymphocytesThermodynamicsCommentJournal Article

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David H Margulies. 2003. Molecular interactions: stiff or floppy (or somewhere in between?).. https://doi.org/10.1016/s1074-7613(03)00331-5

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