Tumbling down a different pathway to genetic instability.

Haiwei H Guo; Lawrence A Loeb

doi:10.1172/jci20502

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PubMed · 14679175

Tumbling down a different pathway to genetic instability.

Haiwei H Guo·Lawrence A Loeb

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Abstract

Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.

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Base Sequence Colitis, Ulcerative DNA Damage DNA Glycosylases DNA Repair DNA Sequence, Unstable DNA-(Apurinic or Apyrimidinic Site) Lyase Humans Inflammation Microsatellite Repeats Models, Biological Molecular Sequence Data Mutation Comment Journal Article Review

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Haiwei H Guo, Lawrence A Loeb. 2003. Tumbling down a different pathway to genetic instability.. https://doi.org/10.1172/jci20502

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