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Summing up ligand binding interactions.

David A Leigh
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Abstract

Artificial molecular recognition systems show negligible positive binding cooperativity compared to biological systems, possibly because rigid ligands cannot accommodate numerous partly bound states that comprise overall ligand binding affinity. This directly correlates with the phenomenon of enthalpy-entropy compensation.

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Allosteric RegulationLigandsThermodynamicsCommentJournal Article

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David A Leigh. 2003. Summing up ligand binding interactions.. https://doi.org/10.1016/j.chembiol.2003.12.006

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