PubMed · 14711136
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James Wharton. 2003. Beware confusing micrograms and milligrams.. https://pubmed.ncbi.nlm.nih.gov/14711136/
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A novel method for analysis of hydrophobic drug molecules in matrices that contain Cremophor EL (CrEL) is presented. The method utilized a precipitation technique involving mercuric chloride in a reaction with CrEL to form an insoluble complex in an ethanol matrix. The hydrophobic drug molecule was then analyzed by HPLC-UV without interference from CrEL. Nuclear magnetic resonance and infrared spectroscopy indicated that the mechanism of precipitation involves the reaction of mercuric chloride with the ether bond of CrEL. Analysis by HPLC with UV detection of paclitaxel and related substances was used to verify that the reaction is specific toward CrEL.
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Micelle-associated epoetin is still a possible explanation for the upsurge of pure red blood cell aplasia associated with subcutaneous use of epoetin alpha in patients with chronic renal failure.