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PubMed · 14722943

Cutaneous leishmaniasis in Al-Badarna: a prospective study among school children.

A A el-Buni·A L Ben-Darif·I Taleb·A Refai
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Abstract

This paper presents the results of a prospective study cutaneous liashmaniasis in 2 schools in Al-Badarna, during the period from July to December 1992. The pupils were interviewed and examined. Positive cases were referred to the Health Unit for treatment. Of 260 pupils 22 (8.46%) were found to be infected with active lesions.

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Antimony Sodium GluconateAntiprotozoal AgentsBiopsyChildEndemic DiseasesFemaleHumansLeishmaniasis, CutaneousLibyaMaleNeeds AssessmentPopulation SurveillancePrevalenceProspective StudiesReferral and ConsultationRural HealthSex DistributionStudentsSurveys and QuestionnairesJournal Article

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A A el-Buni, A L Ben-Darif, I Taleb, A Refai. Cutaneous leishmaniasis in Al-Badarna: a prospective study among school children.. https://pubmed.ncbi.nlm.nih.gov/14722943/

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HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis.

Leishmaniasis is an important opportunistic disease among patients infected with human immunodeficiency virus (HIV)-1. The pentavalent antimony compound sodium stibogluconate is a drug of choice for the treatment of leishmaniasis. Because sodium stibogluconate acts as an inhibitor of phosphotyrosyl phosphatases and such inhibitors can promote HIV-1 replication, we tested the effect of this compound on virus gene expression. Using pseudotyped reporter viruses and fully infectious laboratory-adapted and clinical strains of HIV-1, we report that sodium stibogluconate induces an increase in HIV-1 transcription and virus replication in primary CD4(+) T cells and in thymic histocultures. This activation is a slow process and appears to involve the transcription factors nuclear factor- kappa B and activator protein 1, as well as the Syk, Jun, and mitogen-activated protein kinase/extracellular signal-related kinase signal-transduction pathways. In addition, the effect seems to be partly mediated by a soluble factor. Altogether, these findings might reveal clinical implications for the treatment of leishmaniasis in HIV-1-infected patients.

Antimony Sodium Gluconate↗