PubMed Health⌕ Search

PubMed · 14728470

Using description logic to manage question corpora.

Abstract

If clinical questions are to be used on a large scale as a practitioner interface to the medical knowledge base, improved methods must be developed for the semantic management of question corpora. In this project we investigate the use of description logic to manage question corpora. We propose the addition of a Q-box to a standard Description Logic knowledge base. The Q-box will contain concept descriptions that are not yet accepted as part of the T-box, but in effect represent questions about concepts already described in the T-box.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Timothy B Patrick. 2003. Using description logic to manage question corpora.. https://pubmed.ncbi.nlm.nih.gov/14728470/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability.

BACKGROUND: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and comparison methods combined with rapidly increasing sequence data often can reliably match even distantly related proteins that share little sequence similarity. However, even highly significant matches generally may have incorrectly aligned regions. Therefore when exact residue correspondence is used to transfer biological information from one aligned sequence to another, it is critical to know which alignment regions are reliable and which may contain alignment errors. RESULTS: PSI-BLAST-ISS is a standalone Unix-based tool designed to delineate reliable regions of sequence alignments as well as to suggest potential variants in unreliable regions. The region-specific reliability is assessed by producing multiple sequence alignments in different sequence contexts followed by the analysis of the consistency of alignment variants. The PSI-BLAST-ISS output enables the user to simultaneously analyze alignment reliability between query and multiple homologous sequences. In addition, PSI-BLAST-ISS can be used to detect distantly related homologous proteins. The software is freely available at: http://www.ibt.lt/bioinformatics/iss. CONCLUSION: PSI-BLAST-ISS is an effective reliability assessment tool that can be useful in applications such as comparative modelling or analysis of individual sequence regions. It favorably compares with the existing similar software both in the performance and functional features.

Information Storage and Retrieval↗

Communication boundaries in networks.

We investigate and quantify the interplay between topology and the ability to send specific signals in complex networks. We find that in a majority of investigated real-world networks the ability to communicate is favored by the network topology at small distances, but disfavored at larger distances. We further suggest how the ability to locate specific nodes can be improved if information associated with the overall traffic in the network is available.

Information Storage and Retrieval↗