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PubMed · 14762923

Responsive and recognitive hydrogels using star polymers.

Ebru Oral·Nicholas A Peppas
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Abstract

Polymeric networks that have inherent capabilities to recognize different molecules and chemical changes in their environment are the next generation of materials that will aid in the diagnosis and treatment of diseases. We have prepared new networks based on star polymers that were designed to be responsive and recognitive. Using molecular imprinting with D-glucose and crosslinking with poly(ethylene glycol) dimethacrylate with an ethylene glycol chain of nominal molecular weight 600, we prepared star polymer networks, which exhibited over 300% more uptake for D-glucose compared to D-fructose. Using copolymerization with methacrylic acid, we prepared star polymer networks with pH-sensitivity, which showed a sharp transition in swelling around a pH of 4.5.

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AcrylatesCross-Linking ReagentsDrug Delivery SystemsGlucoseHydrogelsHydrogen-Ion ConcentrationMethacrylatesModels, TheoreticalPolyethylene GlycolsPolymersJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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Ebru Oral, Nicholas A Peppas. 2004-03-01. Responsive and recognitive hydrogels using star polymers.. https://doi.org/10.1002/jbm.a.20076

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