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PubMed · 1491446

[Interleukin 6 (IL-6)].

K Dohi·M Iwano·Y Horii
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Abstract

Interleukin 6 (IL-6) is a polypeptide mediator regulating immune response, acute phase reaction and hematopoiesis. Disregulating production of IL-6 was suggested to be involved in a variety of chronic inflammatory diseases. IL-6 is an autocrine growth factor for cultured mesangial cells. IL-6 was localized in the mesangial area of the kidney tissue and intraglomerular expression of mRNA, encoding for IL-6 gene, was observed in patients with mesangial proliferative glomerulonephritis (mes PGN). Furthermore, mesangial proliferation was observed in IL-6 transgenic mice. These results suggest that IL-6 is closely associated with the pathogenesis of mesPGN.

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AnimalsCells, CulturedGlomerular MesangiumHumansInterleukin-6Kidney GlomerulusMiceNephritisRNA, MessengerReceptors, ImmunologicReceptors, Interleukin-6Signal TransductionEnglish AbstractJournal ArticleReview

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K Dohi, M Iwano, Y Horii. 1992. [Interleukin 6 (IL-6)].. https://pubmed.ncbi.nlm.nih.gov/1491446/

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