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The eosinophil enigma.

Timothy J Williams
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Abstract

Eosinophils accumulate in high numbers in the lungs of asthmatic patients. These cells have the ability to induce tissue damage, a capacity that relates to their traditional role in host defense against parasitic worms. On the other hand, eosinophils produce growth factors associated with tissue repair and remodeling, notably TGF-beta1. The relationship of these activities to lung dysfunction in asthma is highly controversial, but recent observations in humans and in animal models add spice to the debate.

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AnimalsAsthmaEosinophilsHumansInterleukin-5Transforming Growth Factor betaTransforming Growth Factor beta1CommentJournal Article

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Timothy J Williams. 2004. The eosinophil enigma.. https://doi.org/10.1172/jci21073

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