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Confidence bands for low-dose risk estimation with quantal response data.

Obaid M Al-Saidy·Walter W Piegorsch·R Webster West·Daniela K Nitcheva
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Abstract

We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

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BiometryComputer SimulationConfidence IntervalsEnvironmental ExposureHumansModels, StatisticalMonte Carlo MethodQuantum TheoryReproducibility of ResultsRiskComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Obaid M Al-Saidy, Walter W Piegorsch, R Webster West, Daniela K Nitcheva. 2003. Confidence bands for low-dose risk estimation with quantal response data.. https://doi.org/10.1111/j.0006-341x.2003.00121.x

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