Study of glimepiride-b-cyclodextrin complex.

J R Moyano; T Ventriglia; J M Ginés; F Muñoz; A M Rabasco

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PubMed · 14971307

Study of glimepiride-b-cyclodextrin complex.

J R Moyano·T Ventriglia·J M Ginés·F Muñoz·A M Rabasco

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Abstract

The interaction of glimepiride with b-cyclodextrin (b-CD) has been studied by several analytical techniques, including 1H NMR, infrared spectroscopy (FTIR), powder x-ray diffractometry (XRD), thermal analysis (DSC) and scanning electron microscopy (SEM). The existence of an inclusion complex was proved in solution by phase solubility techniques and 1H NMR, and in the solid state by DSC, FTIR and XRD, being isolated by sealed heating and freeze drying procedures.

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Calorimetry, Differential Scanning Chemical Phenomena Chemistry, Physical Cyclodextrins Drug Compounding Hypoglycemic Agents Kinetics Microscopy, Electron, Scanning Solubility Spectroscopy, Fourier Transform Infrared Sulfonylurea Compounds X-Ray Diffraction Journal Article

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J R Moyano, T Ventriglia, J M Ginés, F Muñoz, A M Rabasco. 2003. Study of glimepiride-b-cyclodextrin complex.. https://pubmed.ncbi.nlm.nih.gov/14971307/

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