Actin lessons from pathogens.

Christophe Le Clainche; David G Drubin

doi:10.1016/s1097-2765(04)00088-7

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PubMed · 14992714

Actin lessons from pathogens.

Christophe Le Clainche·David G Drubin

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Abstract

Salmonella typhimurium secretes proteins that co-opt the host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacterium. New information about the biochemical activities of the Salmonella protein SipA suggests that this protein might inhibit host cell actin dynamics by competing with ADF/cofilin and gelsolin, two key proteins that promote the turnover of actin filaments.

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Actin Depolymerizing Factors Actins Animals Bacterial Proteins Binding Sites Destrin Enzyme Activation Gelsolin Humans Microfilament Proteins Salmonella typhimurium rho GTP-Binding Proteins Comment Journal Article Review

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Christophe Le Clainche, David G Drubin. 2004-02-27. Actin lessons from pathogens.. https://doi.org/10.1016/s1097-2765(04)00088-7

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