Active-site dynamics in RNA polymerases.

Robert Landick

doi:10.1016/s0092-8674(04)00121-7

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Active-site dynamics in RNA polymerases.

Robert Landick

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Abstract

New crystal structures of transcription complexes formed by bacteriophage T7 RNA polymerase reveal a nucleotide-addition cycle driven by active-site conformational changes similar to those observed in DNA polymerases, and suggest provocative hypotheses for the more complex multisubunit RNA polymerases of free-living organisms.

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Animals Binding Sites DNA-Directed DNA Polymerase DNA-Directed RNA Polymerases Gene Expression Regulation, Viral Humans Molecular Conformation Nucleotides RNA, Messenger Translocation, Genetic Viral Proteins Comment Journal Article Review

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Robert Landick. 2004-02-06. Active-site dynamics in RNA polymerases.. https://doi.org/10.1016/s0092-8674(04)00121-7

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