The relationship between peptide structure and antibacterial activity.

Jon-Paul S Powers; Robert E W Hancock

doi:10.1016/j.peptides.2003.08.023

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PubMed · 15019199

The relationship between peptide structure and antibacterial activity.

Jon-Paul S Powers·Robert E W Hancock

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Abstract

Cationic antimicrobial peptides are a class of small, positively charged peptides known for their broad-spectrum antimicrobial activity. These peptides have also been shown to possess anti-viral and anti-cancer activity and, most recently, the ability to modulate the innate immune response. To date, a large number of antimicrobial peptides have been chemically characterized, however, few high-resolution structures are available. Structure-activity studies of these peptides reveal two main requirements for antimicrobial activity, (1) a cationic charge and (2) an induced amphipathic conformation. In addition to peptide conformation, the role of membrane lipid composition, specifically non-bilayer lipids, on peptide activity will also be discussed.

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Animals Antimicrobial Cationic Peptides Cell Membrane Membrane Lipids Protein Conformation Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

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Jon-Paul S Powers, Robert E W Hancock. 2003. The relationship between peptide structure and antibacterial activity.. https://doi.org/10.1016/j.peptides.2003.08.023

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