PubMed · 15055398
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Stephen C Strother. 2003. A developer's commentary on Fiswidgets.. https://doi.org/10.1385/ni%3A1%3A1%3A131
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Eight docking programs (DOCK, FLEXX, FRED, GLIDE, GOLD, SLIDE, SURFLEX, and QXP) that can be used for either single-ligand docking or database screening have been compared for their propensity to recover the X-ray pose of 100 small-molecular-weight ligands, and for their capacity to discriminate known inhibitors of an enzyme (thymidine kinase) from randomly chosen "drug-like" molecules. Interestingly, both properties are found to be correlated, since the tools showing the best docking accuracy (GLIDE, GOLD, and SURFLEX) are also the most successful in ranking known inhibitors in a virtual screening experiment. Moreover, the current study pinpoints some physicochemical descriptors of either the ligand or its cognate protein-binding site that generally lead to docking/scoring inaccuracies.
In the Korean market there are several respirators for industrial purposes. Some of them are imported from global manufacturers such as 3M, and the others are developed by domestic companies. However, some of the locally made respirators have a face-seal leakage problem because they were not designed taking into account Korean facial characteristics. This pilot study was conducted to develop three face models for a half-mask based on the Korean fit-test panel and also to design three well-fitting silicon prototypes (large, medium and small) for Korean faces. For a test panel, 50 subjects were selected on the basis of lip length and face length. Shapes of faces from the test panel were scanned by a 3D scanner (Vivid 900, Minolta). The facial dimension scales for three size groups were established through statistical analysis. To ensure that the shapes fit the mean facial dimensions of each size group, similarly shaped sample faces were selected from the test panel. Mean faces with representative facial dimensions as well as face models (mannequins) were made by the Rapid Prototyper (RP; Z400, Z Corps, USA). These were reshaped to fit the mean faces by clay-modeling. The face models were digitized to recheck the fit of the facial dimensions. On the basis of the face models, three types of masks were developed through digital modeling, and tangible models were prototyped by RP. Three differently sized prototype masks were made with silicon and examined by simple naked eye test. This procedure established the mask design process based on digital technology; it can be applied for similar design projects in the future. Further study is needed to verify whether these prototypes would be a good fit for Korean faces.
BACKGROUND: When publishing large-scale microarray datasets, it is of great value to create supplemental websites where either the full data, or selected subsets corresponding to figures within the paper, can be browsed. We set out to create a CGI application containing many of the features of some of the existing standalone software for the visualization of clustered microarray data. RESULTS: We present GeneXplorer, a web application for interactive microarray data visualization and analysis in a web environment. GeneXplorer allows users to browse a microarray dataset in an intuitive fashion. It provides simple access to microarray data over the Internet and uses only HTML and JavaScript to display graphic and annotation information. It provides radar and zoom views of the data, allows display of the nearest neighbors to a gene expression vector based on their Pearson correlations and provides the ability to search gene annotation fields. CONCLUSIONS: The software is released under the permissive MIT Open Source license, and the complete documentation and the entire source code are freely available for download from CPAN http://search.cpan.org/dist/Microarray-GeneXplorer/.