PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 15068570

Fatal overdosage with cisplatin.

C Charlier·P Kintz·N Dubois·G Plomteux
View original source ↗Export metadata ↓

Abstract

This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart and peripheral blood concentrations of platinum were 1515 and 1253 micro g/L, respectively. Concentrations in urine and bile were 1038 and 501 micro g/L, respectively. Renal dialysis was started immediately after the end of cisplatin perfusion, when the mistake was noticed, but the patient deceased at day 16, presenting renal and hepatic insufficiency, ototoxicity, and pancytopenia.

Explore related subjects

AccidentsAntineoplastic AgentsCause of DeathCisplatinDrug OverdoseFatal OutcomeGas Chromatography-Mass SpectrometryHumansMaleMiddle AgedCase ReportsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

C Charlier, P Kintz, N Dubois, G Plomteux. 2004. Fatal overdosage with cisplatin.. https://doi.org/10.1093/jat%2F28.2.138

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Vocational rehabilitation of locomotive engineers with ischaemic heart disease.

BACKGROUND: There is resistance among railway companies and their occupational health services to rehabilitating locomotive engineers with ischaemic heart disease to their former driving work. AIM: To study the outcome of vocational rehabilitation for locomotive engineers with ischaemic heart disease. METHODS: In seven European countries, selected locomotive engineers with ischaemic heart disease were compared to a matched group of healthy engineers. At the end of each calendar year between 1990 and 1999, questionnaires were completed by local occupational health physicians to provide information on accidents, incidents (professional mistakes), sick leave, (recurrent) cardiac events, death and early retirement. We used the life table method with five follow-up years to calculate the risk of accidents, incidents and recurrent cardiac events. RESULTS: The accident rate for the cardiac group was 3.8 accidents per 100 person-years, as compared to a rate of 6.0 in the reference group. The rates for incidents were 0.9 and 2.0, respectively. Neither of these differences were statistically significant. The duration of sick leave was significantly longer among the cardiac group than it was among the reference group, but only in the first follow-up year. Thirteen recurrent cardiac events occurred in the cardiac group, as compared to a single cardiac event in the reference group. There was no difference in the proportion of retirement cases. One engineer in each of the two groups died of cardiac disease. CONCLUSIONS: Locomotive engineers can safely resume driving duties following onset of cardiac disease.

Accidents↗
PubMed2007

Contribution of initial heart rate to the prediction of posttraumatic stress symptom level in accident victims.

Earlier findings of a positive correlation between heart rate (HR) and posttraumatic symptom level have recently been brought into question. Therefore, we investigated the relationship between resting HR and symptom scores of posttraumatic stress disorder (PTSD) in physically injured accident survivors, controlling for well established predictors for (PTSD and factors influencing HR. A representative sample of 255 accident victims was assessed measuring PRIME-MD, PDEQ, trauma-related cognitions and CAPS. Initial interviews were conducted five days post trauma; follow-up assessments took place six months later. Heart rate measurements were obtained from surgical files. We found positive bivariate correlations between HR at hospital admission (HRA) and PTSD symptom levels. However, in multiple regression analysis HRA contributed marginally to the prediction of PTSD symptom levels. We conclude that the initial heart rate is a weak and not independent predictor for PTSD symptom level following accidental injuries.

Accidents↗
PubMed2007

[Oxygen therapy in diving accidents].

Diving accidents represent a departure from the routine practice of emergency physicians. The incidence of non-fatal diving accidents is reported as 1-2 per 10,000 dives. Apart from adequate intravenous hydration, oxygen is the only medication with a proven effect in the treatment of diving accidents. After a typical diving accident, administration of oxygen at an inspired concentration (F(I)O(2) 1.0) as high as possible is recommended. Many divers bring along their own oxygen administration systems to the diving sites and these are often better suited for the treatment of diving accidents than the oxygen systems of many emergency responders. Pressure regulators supplying low constant flow oxygen, nasal prongs and inhalation masks are inappropriate. When using artificial ventilation bags with face masks, an oxygen flow of at least 15 l/min should be used. Demand regulators are simple to use and able to deliver a F(I)O2 of 1.0. Their ease of use has earned them high marks in the emergency management of diving accidents and their similarity to standard diving equipment has also aided relatively widespread acceptance. Circulation breathing systems are more technologically complex oxygen delivery systems which permit CO2 absorption and re-breathing at low oxygen flow. In contrast to the demand modules, the likelihood of mistakes during their usage is higher. In diving accidents, the administration of normobaric oxygen, already begun in the field, is the most important therapy and should not be interrupted. Presented with an inadequate supplemental oxygen supply, the inspired oxygen concentration should not be decreased, rather the duration of the oxygen administration should be reduced. Hyperbaric oxygen therapy should be the mainstay of further treatment.

Accidents↗