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Experimental autoimmune hearing loss.

Peter Billings
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Abstract

Understanding of autoimmune sensorineural hearing loss (ASNHL) has been hindered by the inaccessibility of the inner ear to biopsy and the lack of workable animal models. A report in this issue of the JCI describes a mouse model of CD4(+) T cell-mediated ASNHL induced by immunization with peptides from the inner ear-specific proteins cochlin and beta-tectorin.

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AnimalsAutoimmune DiseasesCD4-Positive T-LymphocytesDisease Models, AnimalExtracellular Matrix ProteinsGPI-Linked ProteinsHearing Loss, SensorineuralImmunizationMembrane ProteinsMiceProteinsCommentJournal Article

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Peter Billings. 2004. Experimental autoimmune hearing loss.. https://doi.org/10.1172/jci21632

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