[Endogenous hyperlactatemia and insulin secretion].

G Ribes; G Valette; F Lignon; M M Loubatières-Mariani

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PubMed · 150887

[Endogenous hyperlactatemia and insulin secretion].

G Ribes·G Valette·F Lignon·M M Loubatières-Mariani

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Abstract

In the normal anesthetized dog, the endogenous hyperlactatemia induced either by intense muscular work or by a high dose of phenformin (20 mg/kg subtucaneously) is followed by an increase in the pancreaticoduodenal insulin output. A previous perfusion of sodium dichloroacetate (50 mg/kg. h) opposes the hyperlactatemia, and reduces or suppresses the increase in insulin output.

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Animals Dichloroacetic Acid Dogs Insulin Insulin Secretion Kinetics Lactates Phenformin Physical Exertion Journal Article

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G Ribes, G Valette, F Lignon, M M Loubatières-Mariani. 1978. [Endogenous hyperlactatemia and insulin secretion].. https://pubmed.ncbi.nlm.nih.gov/150887/

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