Microtechnologies and nanotechnologies for single-cell analysis.

Helene Andersson; Albert van den Berg

doi:10.1016/j.copbio.2004.01.004

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Microtechnologies and nanotechnologies for single-cell analysis.

Helene Andersson·Albert van den Berg

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Abstract

Many efforts are currently underway to try and mimic the properties of single cells with the aim of designing chips that are as efficient as cells. However, cells are nature's nanotechnology engineering at the scale of atoms and molecules, and it might be better to envision a microchip that utilizes a single cell as an experimentation platform. A novel, so-called laboratory-in-a-cell concept has been described, where advantage is taken of micro- and nanotechnological tools to enable precise control of the biochemical cellular environment; these tools also offer the possibility to analyse the composition of single cells. Methods for single-cell handling and analysis are being developed and will be required for this concept to progress further.

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Animals Cell Culture Techniques Cell Physiological Phenomena Cells, Cultured Electrophoresis Equipment Design Flow Cytometry Humans Microfluidics Micromanipulation Miniaturization Nanotechnology Patch-Clamp Techniques Journal Article Research Support, Non-U.S. Gov't Review

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Helene Andersson, Albert van den Berg. 2004. Microtechnologies and nanotechnologies for single-cell analysis.. https://doi.org/10.1016/j.copbio.2004.01.004

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