PubMed · 15104384
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Fernando Cendes. 2003. Partial epilepsies: overview.. https://pubmed.ncbi.nlm.nih.gov/15104384/
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Laughter epilepsy or gelastic seizures have been described in various epilepsies arising from the temporal or frontal lobes, but most commonly from hypothalamic hamartomata. Gelastic seizures also arise from temporal and frontal lobe tumours and atrophic lesions. The essential clinical features are: stereotyped recurrence; absence of external precipitants; concomitance of other manifestations generally accepted as epileptic; presence of interictal or interictal EEG epileptiform discharges, and absence of conditions in which pathological laughter might occur. The history and clinical significance are discussed.
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This article provides an overview of novel MR image analysis methods applied to the quantitative assessment of the neocortex in various forms of epilepsy. Postacquisition processing methods, such as voxel-based morphometry and texture analysis, involve the use of computer software to manipulate, enhance, and classify image information in a digital format. These techniques have the potential to demonstrate subtle abnormalities that are not identified by eye because of anatomic variability. Information provided by quantitative MR imaging of the neocortex may be important for the identification of accurate predictors of surgical outcome and may refine the selection of surgical candidates, particularly those with "nonlesional" neocortical epilepsy.