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PubMed · 15112991

Orthogonal base pairs continue to evolve.

Donald E Bergstrom
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Abstract

Recent developments in the design and construction of unusual analogs of the natural nucleic acid bases have reached a milestone with the report (in this issue of Chemistry & Biology) of a new orthogonal base pair that allows site-specific introduction of a photo-crosslinkable modified base into an RNA molecule by T7 RNA polymerase-mediated transcription of DNA containing the base-pairing partner.

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Base PairingCross-Linking ReagentsCytosineDNADNA-Directed RNA PolymerasesGuanineNucleic AcidsPurinesPyridinesRNATranscription, GeneticViral ProteinsCommentJournal Article

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Donald E Bergstrom. 2004. Orthogonal base pairs continue to evolve.. https://doi.org/10.1016/j.chembiol.2004.01.007

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