PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 15123256

Profiling natural product biosynthesis.

Brenda A Frankel·Dewey G McCafferty
View original source ↗Export metadata ↓

Abstract

Natural products are a rich source of therapeutics; however, artificially reengineering the biosynthetic pathways that generate these compounds could potentially generate "designer" drugs. Last month in Chemistry & Biology, Burkart and coworkers reported their technique to track and better understand the components of these pathways.

Explore related subjects

Biological FactorsMacrolidesMultienzyme ComplexesPeptide SynthasesPeptidesCommentJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Brenda A Frankel, Dewey G McCafferty. 2004. Profiling natural product biosynthesis.. https://doi.org/10.1016/j.chembiol.2004.03.007

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

C-type natriuretic peptide: a new endothelium-derived hyperpolarizing factor?

Vascular relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF) is important for resistance artery function and is underpinned by hyperpolarization of the smooth muscle cells of the blood vessel wall. Debate surrounds the identity of EDHF and its mechanism of action, with the consensus being that there is no universal EDHF. Regional differences in vascular function reflect the complex mechanisms of EDHF. Two primary mechanistic pathways are implicated: (i) myoendothelial gap junctions mediating the spread of endothelial cell hyperpolarization or small signaling molecules (or both) to the smooth muscle; and (ii) diffusible mediators released from the endothelium, including K+ and epoxyeicosatrienoic acids. Here, we discuss the evidence for and against C-type natriuretic peptide (CNP), the latest candidate for a diffusible mediator.

Biological Factors↗